Protein regulator shows promise against addiction 1
The miR-212 microRNA blocks an inhibitor of Raf1 in the striatum, a part of the brain involved in learning habits like driving a car and learning to avoid making the same mistake twice. With its inhibitor in check, Raf1 is free to stimulate CREB production, Kenny and his colleagues show in the new study.Microsoft Office 2007 can give you more convenient life.
Protecting against cocaine addiction may be a side benefit of mir-212’s normal job of regulating CREB production and other biochemical processes in the brain, Kenny says. The microRNA helps set the correct level of CREB production to keep it from getting too low, which leads to addiction and anxiety, or too high, which leads to depression.
Any therapy targeting CREB would have to strike this delicate balance as well, he says. “Obviously there could be some very profound side effects,” Kenny says.Office 2007 download is helpful!
The researchers are investigating how mir-212 is regulated and whether it is protective against addiction to other drugs, such as nicotine and alcohol.
Every so often in New York City, a disk of cast iron weighing up to 300 pounds will burst out of the street and fly as high as several stories before clattering back to the blacktop. Flames, smoke or both may issue from the breach, as if somebody had pulled hell’s own pop-top.
Manhole explosions aren’t just spectacular; they’re dangerous. As one firefighter observed after a manhole exploded near Times Square in May: “It’s not Disneyland, people. Get the hell out of the way.”The invention of Microsoft Office 2010 is a big change of the world.
Ever since Thomas Edison fired up the city’s commercial electric grid in 1882, New Yorkers have had to contend with the random hazards of smoking, flaming and exploding manholes. Many of the blasts result from decrepit wiring, which can lead to sparks. Throw in a bit of gas and a confined space and, like a combustion engine, the blast can move metal. Until recently, there was no way of knowing where or when the next outburst would occur; repairs commenced only after a manhole had growled.